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Date: Wed, 14 Jan 2004 22:53:32 +0100
From: Andy Bogard <pympe1@???>
Subject: ansa.it - Fatto del giorno
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ansa.it - Fatto del giornoNei vermi recettori che si legano con il =
Prozac.
Bush prende il Prozac.
Bush =E8 un verme....
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Ambiente =20
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Beni Culturali Sicilia=20
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Agroalimentare Lazio =20
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Agroalimentare Sicilia=20
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Genova 2004 =20
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Torino 2006 =20
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News locali =20
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Moda=20
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Toto e lotterie=20
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Gazzetta Ufficiale=20
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Canale Turismo=20
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Concorso Grinzane Cavour-Ansa "Comunicare la =
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Scienza e Tecnica=20
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Qualit=E0 Alto Adige=20
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I FATTI DEL GIORNO =20
NOBEL HORVITZ: NEI VERMI IL SEGRETO DELLA FELICITA' =20
ROMA - Il segreto della felicita'? Potrebbe =
nascondersi in un vermiciattolo lungo appena un millimetro, ma che ha =
permesso scoperte cruciali nella storia della biologia. Nel sistema =
nervoso della Caenorhabditis elegans sono stati scoperti recettori =
capaci di legarsi ad uno dei piu' noti farmaci antidepressivi, il =
Prozac, il cui meccanismo d'azione e' ancora misterioso sotto molti =
aspetti.
Lo ha detto oggi a Roma il Nobel Robert Horvitz, a =
margine della cerimonia nella quale ha ricevuto la laurea ad honorem =
dall'universita' di Tor Vergata. Cosi' come studiare il semplice =
patrimonio genetico del C. elegans ha permesso di capire i meccanismi =
che spingono le cellule al suicidio, aprendo la via a nuove terapie =
anticancro, ci sono buone speranze che anche lo studio del suo =
comportamento e del suo sistema nervoso permettano di scoprire alcuni =
dei numerosi segreti del cervello umano. ''Stiamo diventando psicologi =
dei vermi'', ha detto scherzando Horvitz, che da oltre due anni ha =
inaugurato questo filone di ricerche con il suo gruppo presso il =
Massachussetts Institute of Technology (MIT).
''L'idea di partenza - ha detto - e' stata studiare il =
modo in cui la genetica si evolve, dando origine a comportamenti =
specifici. Cosi' ci siamo messi ad osservare il modo in cui C. elegans =
si muove, risponde a stimoli ambientali e alle esperienze del mondo =
esterno''. Horvitz e il suo gruppo hanno scoperto cosi' che anche il =
vermetto ha insospettabili cambianti di umore, dietro i quali si =
nasconde un nuovo tipo di serotonina, il neurotrasmettitore noto da =
tempo per gli effetti che esercita sull'umore e la cui produzione viene =
stimolata da farmaci antidepressivi, come il Prozac.
Nell'uomo alti livelli di questa sostanza sono =
positivi, mentre bassi livelli scatenano depressione, irritabilita', =
insonnia, mal di testa. Sembra che nel C. elegans il neurotrasmettitore =
funzioni allo stesso modo. ''Abbiamo imparato a capire quando un verme =
e' felice'', ha detto ancora Horvitz. ''Cio' che attrae di piu' un verme =
e' il cibo - ha osservato - e sappiamo che giunto in vicinanza di =
qualcosa da mangiare comincia a rallentare il suo movimento e ad agitare =
rapidamente le mascelle. Quando la C. elegans si comporta cosi' sappiamo =
che e' felice. Un verme felice, inoltre, depone piu' facilmente le uova, =
e questo e' un altro inzio utile per comprenderne se e' felice o meno''. =
Horvitz e i suoi collaboratori hanno osservato cosi' che se i livelli di =
serotonina sono elevati il verme si muove piu' velocemente, agita le =
mascelle e depone le uova, proprio come quando e' soddisfatto per un =
buon pasto. ''Quella che abbiamo osservato nei nuovi recettori della =
serotonina scoperti nel C. elegans - ha aggiunto il Nobel - e' un'azione =
molto rapida e completamente nuova. Continuare lungo questo filone di =
ricerca ci permettera' di comprendere meglio l'azione di farmaci come il =
Prozac. Pensiamo che scoprire come queste molecole agiscano nei vermi =
permettera' di capire meglio come questi farmaci agiscono nell'uomo''.=20
14/01/2004 19:28=20
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<DIV><FONT face=3DArial size=3D2>Bush prende il Prozac.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>Bush =E8 un verme....</FONT></DIV>
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<TD><B class=3Dtitolobold> I FATTI DEL GIORNO=20
</B></TD></TR></TBODY></TABLE>
<TABLE cellSpacing=3D4 cellPadding=3D4 width=3D465 =
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<TR vAlign=3Dtop>
<TD height=3D21><IMG height=3D8 =
src=3D"/mainimages/quadgreen.gif"=20
width=3D8> <SPAN class=3Dtestopiccolobold>NOBEL =
HORVITZ: NEI VERMI=20
IL SEGRETO DELLA FELICITA' </SPAN></TD></TR>
<TR>
<TD vAlign=3Dtop>
<P><IMG alt=3DProzac hspace=3D10=20
src=3D"/fdgimages03/1041686580_v_in_USAV_20030104.jpg" =
align=3Dleft vspace=3D5> <SPAN =
class=3Dtestopiccolo>ROMA - Il=20
segreto della felicita'? Potrebbe nascondersi in un=20
vermiciattolo lungo appena un millimetro, ma che ha =
permesso=20
scoperte cruciali nella storia della biologia. Nel =
sistema=20
nervoso della Caenorhabditis elegans sono stati =
scoperti=20
recettori capaci di legarsi ad uno dei piu' noti =
farmaci=20
antidepressivi, il Prozac, il cui meccanismo d'azione =
e'=20
ancora misterioso sotto molti aspetti.<BR>Lo ha detto =
oggi a=20
Roma il Nobel Robert Horvitz, a margine della =
cerimonia nella=20
quale ha ricevuto la laurea ad honorem =
dall'universita' di Tor=20
Vergata. Cosi' come studiare il semplice patrimonio =
genetico=20
del C. elegans ha permesso di capire i meccanismi che =
spingono=20
le cellule al suicidio, aprendo la via a nuove terapie =
anticancro, ci sono buone speranze che anche lo studio =
del suo=20
comportamento e del suo sistema nervoso permettano di =
scoprire=20
alcuni dei numerosi segreti del cervello umano. =
''Stiamo=20
diventando psicologi dei vermi'', ha detto scherzando =
Horvitz,=20
che da oltre due anni ha inaugurato questo filone di =
ricerche=20
con il suo gruppo presso il Massachussetts Institute =
of=20
Technology (MIT).<BR>''L'idea di partenza - ha detto - =
e'=20
stata studiare il modo in cui la genetica si evolve, =
dando=20
origine a comportamenti specifici. Cosi' ci siamo =
messi ad=20
osservare il modo in cui C. elegans si muove, risponde =
a=20
stimoli ambientali e alle esperienze del mondo =
esterno''.=20
Horvitz e il suo gruppo hanno scoperto cosi' che anche =
il=20
vermetto ha insospettabili cambianti di umore, dietro =
i quali=20
si nasconde un nuovo tipo di serotonina, il =
neurotrasmettitore=20
noto da tempo per gli effetti che esercita sull'umore =
e la cui=20
produzione viene stimolata da farmaci antidepressivi, =
come il=20
Prozac.<BR>Nell'uomo alti livelli di questa sostanza =
sono=20
positivi, mentre bassi livelli scatenano depressione,=20
irritabilita', insonnia, mal di testa. Sembra che nel =
C.=20
elegans il neurotrasmettitore funzioni allo stesso =
modo.=20
''Abbiamo imparato a capire quando un verme e' =
felice'', ha=20
detto ancora Horvitz. ''Cio' che attrae di piu' un =
verme e' il=20
cibo - ha osservato - e sappiamo che giunto in =
vicinanza di=20
qualcosa da mangiare comincia a rallentare il suo =
movimento e=20
ad agitare rapidamente le mascelle. Quando la C. =
elegans si=20
comporta cosi' sappiamo che e' felice. Un verme =
felice,=20
inoltre, depone piu' facilmente le uova, e questo e' =
un altro=20
inzio utile per comprenderne se e' felice o meno''. =
Horvitz e=20
i suoi collaboratori hanno osservato cosi' che se i =
livelli di=20
serotonina sono elevati il verme si muove piu' =
velocemente,=20
agita le mascelle e depone le uova, proprio come =
quando e'=20
soddisfatto per un buon pasto. ''Quella che abbiamo =
osservato=20
nei nuovi recettori della serotonina scoperti nel C. =
elegans -=20
ha aggiunto il Nobel - e' un'azione molto rapida e=20
completamente nuova. Continuare lungo questo filone di =
ricerca=20
ci permettera' di comprendere meglio l'azione di =
farmaci come=20
il Prozac. Pensiamo che scoprire come queste molecole =
agiscano=20
nei vermi permettera' di capire meglio come questi =
farmaci=20
agiscono nell'uomo''.</SPAN> <BR><SPAN =
class=3Ddata>14/01/2004=20
19:28</SPAN> <BR clear=3Dleft></P><!-- --->
<P><SPAN class=3Dtestopiccolo><BR><A class=3Dmenu=20
href=3D"/mainhtml/disclaimer.html">=A9 Copyright ANSA =
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--Boundary_(ID_bZHKt3uDrxYQY8Xhs3YUtg)--
--Boundary_(ID_vfQeH5RsTvMIYrk4Pcn0xg)--
